Article

Genome-wide association study of glucocerebrosidase activity modifiers.

2024-06-07

Abstract excerpt

<title>Abstract</title> <p>One of the most common genetic risk factors for Parkinson’s disease (PD) are variants in <italic>GBA1</italic>, which encodes the lysosomal enzyme glucocerebrosidase (GCase). GCase deficiency has been associated with an increased PD risk, but not all individuals with low GCase activity are carriers of <italic>GBA1</italic> mutations, suggesting other factors may be acting as modifiers....

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Literature Corpus work: 0b22a514-d64b-5eb1-a18a-d68cc72fdc4d
DOI: 10.21203/rs.3.rs-4425669/v1

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