Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LRRK2 exonic variants are associated with lysosomal hydrolase activities and lysosphingolipid alterations in Parkinson's disease.

Gene - 5 Oct 2023

Usenko T S, Senkevich K A, Basharova K S, Bezrukova A I, Baydakova G V, Tyurin A A, Beletskaya M V, Kulabukhova D G, Grunina M N, Emelyanov A K, Miliukhina I V, Timofeeva A A, Zakharova E Y, Pchelina S N

Abstract excerpt

Last data demonstrated that exonic variants of LRRK2 (p.G2019S, p.M1646T) may affect the catalytic activity of lysosomal enzyme glucocerebrosidase (GCase) probably through the phosphorylation of Rab10 protein. We aimed to evaluate an association of LRRK2 exonic variants previously associated with alteration of phosphorylation levels for Rab10Thr73 with PD risk in Russian population and analyze an impact of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glucosylceramidase
Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysosomes

Share to Mutation

Share to Parkinson Disease

Share to Sphingolipids

Source

Identifiers

PMID: 37473971
DOI: 10.1016/j.gene.2023.147639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LRRK2 exonic variants are associated with lysosomal hydrolase activities and lysosphingolipid alterations in Parkinson's disease.PMID 37473971Read ↗

The Effect of p.G2019S Mutation in the LRRK2 Gene on the Activity of Lysosomal Hydrolases and the Clinical Features of Parkinson's Disease Associated with p.N370S Mutation in the GBA1 Gene.Semantic proximity Read ↗

<i>LRRK2</i>p.M1646T is associated with glucocerebrosidase activity and with Parkinson’s diseaseSemantic proximity Read ↗

LRRK2 p.M1646T is associated with glucocerebrosidase activity and with Parkinson's disease.Semantic proximity Read ↗

Glucocerebrosidase-associated Parkinson disease: Pathogenic mechanisms and potential drug treatments.Semantic proximity Read ↗

Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson’s diseaseSemantic proximity Read ↗

The role of glucocerebrosidase in Parkinson disease pathogenesis.Semantic proximity Read ↗

Blood lysosphingolipids accumulation in patients with parkinson's disease with glucocerebrosidase 1 mutations.Semantic proximity Read ↗

Altered sphingolipid hydrolase activities and alpha-synuclein level in late-onset schizophreniaSemantic proximity Read ↗

The activities of LRRK2 and GCase are positively correlated in clinical biospecimens and experimental models of Parkinson’s diseaseSemantic proximity Read ↗

Glycosphingolipid metabolism and its role in ageing and Parkinson's disease.Semantic proximity Read ↗

Glucocerebrosidase dysfunction in GBA1 carriers: insights from blood and macrophage analyses.Semantic proximity Read ↗

Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.