Article

Investigation of the mechanisms underlying the regulation of macrophage activation and glomerular inflammation by JunD

2012-01-01

Abstract excerpt

Macrophages are the predominant immune effector cell found in one of the most severe causes of renal failure in humans, crescentic glomerulonephritis (Crgn). The Wistar Kyoto (WLY) rat is uniquely susceptible among rat strains to Crgn and susceptibility genes have previously been mapped to seven quantitative trait loci (Crgn1-7). The AP-1 transcription factor JunD is markedly overexpressed in WKY macrophages and w...

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Literature Corpus work: 7ca7ebd5-d94f-5555-80d4-962d76a771f5
DOI: 10.25560/9766

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