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Article

Characterization of the macrophage transcriptome in glomerulonephritis-susceptible and -resistant rat strains.

Genes and immunity - 1 Mar 2011

Maratou K, Behmoaras J, Fewings C, Srivastava P, D'Souza Z, Smith J, Game L, Cook T, Aitman T

Abstract excerpt

Crescentic glomerulonephritis (CRGN) is a major cause of rapidly progressive renal failure for which the underlying genetic basis is unknown. Wistar-Kyoto (WKY) rats show marked susceptibility to CRGN, whereas Lewis rats are resistant. Glomerular injury and crescent formation are macrophage dependent and mainly explained by seven quantitative trait loci (Crgn1-7). Here, we used microarray analysis in basal and...

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Identifiers

PMID: 21179115
DOI: 10.1038/gene.2010.61
PMCID: PMC3048856

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