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Article

Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility.

Nature genetics - 1 May 2008

Behmoaras Jacques, Bhangal Gurjeet, Smith Jennifer, McDonald Kylie, Mutch Brenda, Lai Ping Chin, Domin Jan, Game Laurence, Salama Alan, Foxwell Brian M, Pusey Charles D, Cook H Terence, Aitman Timothy J

Abstract excerpt

Crescentic glomerulonephritis is an important cause of human kidney failure for which the underlying molecular basis is largely unknown. In previous studies, we mapped several susceptibility loci, Crgn1-Crgn7, for crescentic glomerulonephritis in the Wistar Kyoto (WKY) rat. Here we show by combined congenic, linkage and microarray studies that the activator protein-1 (AP-1) transcription factor JunD is a major...

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Identifiers

PMID: 18443593
DOI: 10.1038/ng.137
PMCID: PMC2742200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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