Article

A multi-omics map of diabetic nephropathy reveals c-Jun as a driver of tubular injury and metabolic stress

2026-06-12

Abstract excerpt

Diabetic nephropathy (DN) is a major cause of end-stage renal disease, yet the molecular mechanisms driving tubular injury and fibrosis remain poorly defined. Here, we integrated single-cell multiplexed protein imaging, spatial transcriptomics, single-nucleus and single-cell RNA sequencing and chromatin accessibility profiling to comprehensively characterize human DN pathology. Our multi-modal analysis precisely m...

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Literature Corpus work: 2c701d11-bc69-5c25-924f-e75577c3f049
DOI: 10.64898/2026.06.09.731164

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