Article
Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy.
Diabetes - 1 Oct 2018
Gurley Susan B, Ghosh Sujoy, Johnson Stacy A, Azushima Kengo, Sakban Rashidah Binte, George Simi E, Maeda Momoe, Meyer Timothy W, Coffman Thomas M
Abstract excerpt
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease worldwide, but its molecular pathogenesis is not well defined, and there are no specific treatments. In humans, there is a strong genetic component determining susceptibility to DN. However, specific genes controlling DN susceptibility in humans have not been identified. In this study, we describe a mouse model combining type 1 diabetes with...
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