Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications.

Kidney international - 1 Sept 2022

Tomaszewski Maciej, Morris Andrew P, Howson Joanna M M, Franceschini Nora, Eales James M, Xu Xiaoguang, Dikalov Sergey, Guzik Tomasz J, Humphreys Benjamin D, Harrap Stephen, Charchar Fadi J

Abstract excerpt

Hypertension is a major cardiovascular disease risk factor and contributor to premature death globally. Family-based investigations confirmed a significant heritable component of blood pressure (BP), whereas genome-wide association studies revealed >1000 common and rare genetic variants associated with BP and/or hypertension. The kidney is not only an organ of key relevance to BP regulation and the development of...

Topics

Blood Pressure
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Hypertension
Kidney
Polymorphism, Single Nucleotide

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35690124
DOI: 10.1016/j.kint.2022.04.045
PMCID: PMC9886011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications.PMID 35690124Read ↗

Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney.Semantic proximity Read ↗

Unravelling the complex genetics of common kidney diseases: from variants to mechanisms.Semantic proximity Read ↗

Genetic and Epigenetic Mechanisms Regulating Blood Pressure and Kidney Dysfunction.Semantic proximity Read ↗

Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targetsSemantic proximity Read ↗

Beyond Blood Pressure: Emerging Pathways and Precision Approaches in Hypertension-Induced Kidney DamageSemantic proximity Read ↗

Distinct and shared genetics of kidney filtration function versus albuminuria revealed by multi-trait GWASSemantic proximity Read ↗

Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatmentsSemantic proximity Read ↗

Genetic mechanisms of human hypertension and their implications for blood pressure physiology.Semantic proximity Read ↗

Genomics of Blood Pressure and Hypertension: Extending the Mosaic Theory Toward Stratification.Semantic proximity Read ↗

Omics of Blood Pressure and Hypertension.Semantic proximity Read ↗

Trans-ethnic genome-wide association study of kidney function provides novel insight into effector genes and causal effects on kidney-specific disease aetiologiesSemantic proximity Read ↗

Disentangling shared genetic etiologies for kidney function and cardiovascular diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.