Article

Inclusion bodies formed by polyglutamine and poly(glycine-alanine) are enriched with distinct proteomes but converge in proteins that are risk factors for disease and involved in protein degradation

2020-05-04

Abstract excerpt

<h4>ABSTRACT</h4> Poly(glycine-alanine) (polyGA) is one of the dipolypeptides expressed in Motor Neuron Disease caused by C9ORF72 mutations and accumulates as inclusion bodies in the brain of patients. Superficially these inclusions are similar to those formed by polyglutamine (polyQ) in Huntington’s disease and both have been reported to form an amyloid-like structure suggesting they might aggregate via similar...

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Literature Corpus work: 7c9f7df4-8d93-537e-8b77-e31b4fee9c83
DOI: 10.1101/2020.05.04.076547

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