Article

Microsatellite expansions hidden within the human dark genome are translated in novel and toxic proteins causing muscle and neurodegenerative diseases

2025-04-17

Abstract excerpt

<title>Abstract</title> <p>The vast majority of the human genome is non-coding with one-half composed of repeated DNA elements, including microsatellites that are short repeated sequences of 1 to 6 nucleotides. Expansion of a subset of these microsatellites is the leading cause of over 60 neurological diseases. However, most of these short tandem repeat expansions are located in sequences annotated as non-coding,...

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Literature Corpus work: c7bd5629-81e7-53c2-a910-d295d2ee8834
DOI: 10.21203/rs.3.rs-6122917/v1

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