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Interactome screening ofC9orf72dipeptide repeats reveals VCP sequestration and functional impairment by polyGA

11 Aug 2021

Abstract excerpt

Repeat expansions in the C9orf72 gene are a common cause of amyotrophic lateral sclerosis and frontotemporal lobar degeneration, two devastating neurodegenerative disorders. One of the proposed mechanisms of GGGGCC repeat expansion is their translation into non-canonical dipeptide repeats, which can then accumulate as aggregates and contribute to these pathologies. There are five different dipeptide repeat...

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PMID: 34534264
DOI: 10.1093/brain/awab300

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