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Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease

7 Feb 2017

Abstract excerpt

Several hereditary neurological and neuromuscular diseases are caused by an abnormal expansion of trinucleotide repeats. To date, there have been 10 of these trinucleotide repeat disorders associated with an expansion of the codon CAG encoding glutamine (Q). For these polyglutamine (polyQ) diseases, there is a critical threshold length of the CAG repeat required for disease, and further expansion beyond this...

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PMID: 28170216
DOI: 10.1021/acs.biochem.6b00936

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