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Article

Misfolded polyglutamine, polyalanine, and superoxide dismutase 1 aggregate via distinct pathways in the cell.

The Journal of biological chemistry - 7 Mar 2014

Polling Saskia, Mok Yee-Foong, Ramdzan Yasmin M, Turner Bradley J, Yerbury Justin J, Hill Andrew F, Hatters Danny M

Abstract excerpt

Protein aggregation into intracellular inclusions is a key feature of many neurodegenerative disorders. A common theme has emerged that inappropriate self-aggregation of misfolded or mutant polypeptide sequences is detrimental to cell health. Yet protein quality control mechanisms may also deliberately cluster them together into distinct inclusion subtypes, including the insoluble protein deposit (IPOD) and the...

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Identifiers

PMID: 24425868
DOI: 10.1074/jbc.M113.520189
PMCID: PMC3945328

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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