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Article

The pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies.

Journal of neurochemistry - 1 Sept 2009

Bauer Peter O, Nukina Nobuyuki

Abstract excerpt

Expansion of CAG trinucleotide repeat within the coding region of several genes results in the production of proteins with expanded polyglutamine (PolyQ) stretch. The expression of these pathogenic proteins leads to PolyQ diseases, such as Huntington's disease or several types of spinocerebellar ataxias. This family of neurodegenerative disorders is characterized by constant progression of the symptoms and...

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PMID: 19650870
DOI: 10.1111/j.1471-4159.2009.06302.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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