Article

Genetic and cellular sensitivity of <i>Caenorhabditis elegans</i> to the chemotherapeutic agent cisplatin

2017-12-12

Abstract excerpt

<h4>ABSTRACT</h4> Cisplatin and derivatives are commonly used as chemotherapeutic agents. Although the cytotoxic action of cisplatin on cancer cells is very efficient, clinical oncologists need to deal with two major difficulties: (i) the onset of resistance to the drug, and (ii) the cytotoxic effect in patients. Here we use Caenorhabditis elegans to investigate factors influencing the response to cisplatin in m...

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Literature Corpus work: 7c9eb81e-333c-503b-bc57-50772a2c5258
DOI: 10.1101/233023

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