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Article

Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models.

Proceedings of the National Academy of Sciences of the United States of America - 7 May 2013

Hedskog Louise, Pinho Catarina Moreira, Filadi Riccardo, Rönnbäck Annica, Hertwig Laura, Wiehager Birgitta, Larssen Pia, Gellhaar Sandra, Sandebring Anna, Westerlund Marie, Graff Caroline, Winblad Bengt, Galter Dagmar, Behbahani Homira, Pizzo Paola, Glaser Elzbieta, Ankarcrona Maria

Abstract excerpt

It is well-established that subcompartments of endoplasmic reticulum (ER) are in physical contact with the mitochondria. These lipid raft-like regions of ER are referred to as mitochondria-associated ER membranes (MAMs), and they play an important role in, for example, lipid synthesis, calcium homeostasis, and apoptotic signaling. Perturbation of MAM function has previously been suggested in Alzheimer's disease...

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PMID: 23620518
DOI: 10.1073/pnas.1300677110
PMCID: PMC3651455

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