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Article

Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice

2023-01-27

Abstract excerpt

Alzheimer’s Disease (AD) has no cure. Earlier, we showed that partial inhibition of mitochondrial complex I (MCI) with small molecule CP2 induces adaptive stress response activating multiple neuroprotective mechanisms. Chronic treatment reduced inflammation, improved synaptic and mitochondrial functions, and blocked neurodegeneration in symptomatic APP/PS1 mice, a translational model of AD. Here, using seria...

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Identifiers and source

Literature Corpus work
845e5986-00e4-584c-8c5c-125157b735a3
DOI
10.20944/preprints202301.0500.v1
Open publication

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Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 MiceDOI 10.20944/preprints202301.0500.v1
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