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Article

Hypothesis: Modulation of microglial phenotype in Alzheimer's disease drives neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2022

Murchison Andrew G

Abstract excerpt

The pathophysiology of Alzheimer's disease (AD) remains to be elucidated. The amyloid hypothesis holds explanatory power but has limitations. This article suggests that amyloid deposition and increased permeability of the blood-brain barrier are independent early events in the disease process, which together fashion a distinct microglial activation phenotype. Downstream events including, phagocytosis of synapses...

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PMID: 34786841
DOI: 10.1002/alz.12503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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