Back to search

Article

A Multiomic Analysis of Cachectic Mice Reveals Cancer Driven Suppression of Muscle Stem Cell Differentiation

2026-01-16

Abstract excerpt

<h4>Summary</h4> Cancer cachexia affects a large proportion of cancer patients, inducing a rapid decline in muscle mass. Patients with cachexia have a worse prognosis and are less responsive to cancer therapies. The exact cause of cachexia remains unknown, nor are there any effective treatments for the condition. In this study, we use the C26 adenocarcinoma cell line to determine how cancer cells affect myofiber...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7c6ed769-e9a2-5f25-90be-f599696fdda2
DOI
10.64898/2026.01.12.699072
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Multiomic Analysis of Cachectic Mice Reveals Cancer Driven Suppression of Muscle Stem Cell DifferentiationDOI 10.64898/2026.01.12.699072
Tumor-induced alterations in single-nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolismSemantic proximity
Bridging the tumor microenvironment: the pivotal role of cancer-associated fibroblasts in tumor cachexia developmentSemantic proximity
Progressive development of melanoma-induced cachexia differentially impacts organ systems in miceSemantic proximity
Activated Oncostatin M signaling drives cancer-associated skeletal muscle wastingSemantic proximity
Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammationSemantic proximity
The Time-Course of Cancer Cachexia Onset Reveals Biphasic Transcriptional Disruptions in Female Skeletal Muscle Distinct from MalesSemantic proximity
Optimization of a mouse model of pancreatic cancer to simulate the human phenotypes of metastasis and cachexia.Semantic proximity
Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexiaSemantic proximity
An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent modelsSemantic proximity
Early adipose tissue wasting in a novel preclinical model of human lung cancer cachexiaSemantic proximity
Pathological features of tissues and cell populations during cancer cachexiaSemantic proximity
Distinct cachexia profiles in response to human pancreatic tumours in mouse limb and respiratory muscleSemantic proximity
Select a neighboring publication to make it the new centre.