Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia

1 Dec 2014

Abstract excerpt

BACKGROUND: Evidence from cachectic cancer patients and animal models of cancer cachexia supports the involvement of Forkhead box O (FoxO) transcription factors in driving cancer-induced skeletal muscle wasting. However, the genome-wide gene networks and associated biological processes regulated by FoxO during cancer cachexia are unknown. We hypothesize that FoxO is a central upstream regulator of diverse gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to FOXO transcription factor regulation
Share to Muscle Physiology and Disorders
Share to Nutrition and Health in Aging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25539728
DOI: 10.1186/1471-2407-14-997

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexiaPMID 25539728Read ↗

A Multiomic Analysis of Cachectic Mice Reveals Cancer Driven Suppression of Muscle Stem Cell DifferentiationSemantic proximity Read ↗

C26 Cancer-Induced Muscle Wasting Is IKKβ-Dependent and NF-kappaB-IndependentSemantic proximity Read ↗

The Pathway to Cancer Cachexia: MicroRNA-Regulated Networks in Muscle Wasting Based on Integrative Meta-AnalysisSemantic proximity Read ↗

An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent modelsSemantic proximity Read ↗

MicroRNA-mRNA Co-sequencing Identifies Transcriptional and Post-transcriptional Regulatory Networks Underlying Muscle Wasting in Cancer CachexiaSemantic proximity Read ↗

Distinct cachexia profiles in response to human pancreatic tumours in mouse limb and respiratory muscleSemantic proximity Read ↗

The canonical ER stress IRE1α/XBP1 pathway mediates skeletal muscle wasting during pancreatic cancer cachexiaSemantic proximity Read ↗

Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle AtrophySemantic proximity Read ↗

Loss of Forkhead Box O3 Facilitates Inflammatory Colon Cancer: Transcriptome Profiling of the Immune Landscape and Novel TargetsSemantic proximity Read ↗

Transcriptome and microRNAome profiling of human skeletal muscle in pancreatic cancer cachexiaSemantic proximity Read ↗

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophySemantic proximity Read ↗

Progressive development of melanoma-induced cachexia differentially impacts organ systems in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.