Article

Early adipose tissue wasting in a novel preclinical model of human lung cancer cachexia

2024-09-30

Abstract excerpt

<h4>Summary</h4> Cancer cachexia (CC), a syndrome of skeletal muscle and adipose wasting, reduces responsiveness to therapies and increases mortality. There are no approved treatments for CC, which may relate to discordance between pre-clinical models and human CC. To address the need for clinically relevant models of lung CC, we generated inducible, lung epithelial cell specific Kras G12D/+ ( G12D ) mice. G1...

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Literature Corpus work: bf4bbe46-c773-55ba-a8b0-16ba4efce70f
DOI: 10.1101/2024.09.27.615385

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