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An integrative transcriptome study reveals Ddit4/Redd1 as a key regulator of cancer cachexia in rodent models

26 Jun 2021

Abstract excerpt

Cancer cachexia is a multifactorial metabolic syndrome that causes up to 20% of cancer-related deaths. Muscle atrophy, the hallmark of cancer cachexia, strongly impairs the quality of life of cancer patients; however, the underlying pathological process is still poorly understood. Investigation of the disease pathogenesis largely relies on cachectic mouse models. In our study, the transcriptome of the cachectic...

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PMID: 34175899
DOI: 10.1038/s41419-021-03932-0

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