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Article

Optimization of a mouse model of pancreatic cancer to simulate the human phenotypes of metastasis and cachexia.

BMC cancer - 4 Apr 2024

Spadafora Victoria, Pryce Benjamin R, Oles Alexander, Talbert Erin E, Romeo Martin, Vaena Silvia, Berto Stefano, Ostrowski Michael C, Wang David J, Guttridge Denis C

Abstract excerpt

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is metastasis which occurs in ~ 80% of PDAC patients. The second is cachexia, which compromises treatment tolerance for patients and reduces their quality of life. Although various mouse models of PDAC exist, recapitulating both metastatic and cachectic...

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Source

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Identifiers

PMID: 38570770
DOI: 10.1186/s12885-024-12104-0
PMCID: PMC10993462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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