Article

Statins suppress cell-to-cell propagation of α-synuclein by lowering cholesterol

2022-11-10

Abstract excerpt

<title>Abstract</title> <p>Cell-to-cell propagation of protein aggregates has been implicated in the progression of neurodegenerative diseases. However, the underlying mechanism and modulators of this process are not fully understood. Here, we screened a small-molecule library in a search for agents that suppress the propagation of α-synuclein and mutant huntingtin (mHtt). These screens yielded several molecules,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c55b1a2-58d1-507c-ae47-1f6b09d6659e
DOI: 10.21203/rs.3.rs-2218027/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Statins suppress cell-to-cell propagation of α-synuclein by lowering cholesterolDOI 10.21203/rs.3.rs-2218027/v1Read

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue ModelSemantic proximity Read

Protein aggregation inhibitors induce divergent transcriptional responses in a cellular model of ɑ-synuclein seeded aggregationSemantic proximity Read

Yeast Reveal a “Druggable” Rsp5/Nedd4 Network that Ameliorates α-Synuclein Toxicity in NeuronsSemantic proximity Read

Suppression and modulation mechanism underlying the flavonoid-induced inhibition of fibrillation of α-synucleinSemantic proximity Read

A <i>de novo</i> compound targeting α-synuclein improves deficits in models of Parkinson's diseaseSemantic proximity Read

shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and ToxicitySemantic proximity Read

Genetic and pharmacological reduction of CDK14 mitigates synucleinopathySemantic proximity Read

Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomersSemantic proximity Read

Condensate-Driven Triglyceride Depletion Links α-Synuclein to Mitochondrial DysfunctionSemantic proximity Read

Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington’s diseaseSemantic proximity Read

Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearanceSemantic proximity Read

Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neuronsSemantic proximity Read