Article

Protein aggregation inhibitors induce divergent transcriptional responses in a cellular model of ɑ-synuclein seeded aggregation

2026-02-02

Abstract excerpt

Parkinson’s disease (PD), dementia with Lewy Bodies (DLB) and multiple system atrophy (MSA) are progressive neurodegenerative disorders marked by the pathological aggregation of alpha-synuclein (ɑSyn). Despite significant research efforts, effective therapeutic interventions remain elusive due to limited understanding of the cellular effects of ɑSyn aggregation and propagation. This study presents the development...

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Literature Corpus work: 0595c0ce-7961-5737-baa0-abb0cca7e674
DOI: 10.64898/2026.01.29.701691

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