Article

Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers

2022-01-27

Abstract excerpt

Alpha-synuclein (α-syn), a major component of Lewy bodies found in Parkinson’s disease (PD) patients, has been found exported outside of cells and may mediate its toxicity via cell-to-cell transmission. Here, we reconstituted soluble, monomeric α-syn secretion by the expression of DnaJ homolog subfamily C member 5 (DNAJC5) in HEK293T cells. DNAJC5 undergoes palmitoylation and anchors on the membrane. Palmitoylatio...

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Literature Corpus work: 31d57c83-3236-581c-a445-27c1b66c54ed
DOI: 10.1101/2022.01.27.477991

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