Article

Biochemical analysis of the endoribonuclease activity of the human mitochondrial topoisomerase 1

2024-03-15

Abstract excerpt

The incorporation of ribonucleotides (rNMPs) into the nuclear genome leads to severe genomic instability, including strand breaks and short 2-5 bp deletions at repetitive sequences. Curiously, the detrimental effects of rNMPs are not observed for the human mitochondrial genome (mtDNA) that typically contains several rNMPs per molecule. Given that the nuclear genome instability phenotype is dependent on the activit...

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Literature Corpus work: 7c09d883-4bbd-5db9-bd1d-a8a796ba38a6
DOI: 10.1101/2024.03.15.585299

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