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Twist and Turn—Topoisomerase Functions in Mitochondrial DNA Maintenance

25 Apr 2019

Abstract excerpt

Like any genome, mitochondrial DNA (mtDNA) also requires the action of topoisomerases to resolve topological problems in its maintenance, but for a long time, little was known about mitochondrial topoisomerases. The last years have brought a closer insight into the function of these fascinating enzymes in mtDNA topology regulation, replication, transcription, and segregation. Here, we summarize the current...

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PMID: 31027213
DOI: 10.3390/ijms20082041

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