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Article

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.

Nucleic acids research - 1 Oct 2009

Dalla Rosa Ilaria, Goffart Steffi, Wurm Melanie, Wiek Constanze, Essmann Frank, Sobek Stefan, Schroeder Peter, Zhang Hongliang, Krutmann Jean, Hanenberg Helmut, Schulze-Osthoff Klaus, Mielke Christian, Pommier Yves, Boege Fritz, Christensen Morten O

Abstract excerpt

Topoisomerase I is essential for DNA metabolism in nuclei and mitochondria. In yeast, a single topoisomerase I gene provides for both organelles. In vertebrates, topoisomerase I is divided into nuclear and mitochondrial paralogs (Top1 and Top1mt). To assess the meaning of this gene duplication, w...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19720733
DOI: 10.1093/nar/gkp708
PMCID: PMC2770673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19720733-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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