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[Mutational and Kinetic Analysis of APE1 Endoribonuclease Activity].

Molekuliarnaia biologiia - 1 Jan 2000

Kuznetsova A A, Gavrilova A A, Novopashina D S, Fedorova O S, Kuznetsov N A

Abstract excerpt

Human apurinic/apyrimidinic endonuclease 1 (APE1) participates in the DNA repair system. It is believed that the main biological function of APE1 is Mg^(2+)-dependent hydrolysis of AP-sites in DNA. On the base of structural data, kinetic studies, and mutation analysis, the key stages of APE1 interaction with damaged DNA were established. It has been shown recently that APE1 can act as an endoribonuclease that...

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Identifiers

PMID: 33871438
DOI: 10.31857/S0026898421020099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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