Article

Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and disease

2023-12-18

Abstract excerpt

Evidence indicates that transposable elements (TEs) can contribute to the evolution of new traits, with some TEs acting as deleterious elements while others are repurposed for beneficial roles in evolution. In mammals, some KRAB-ZNF proteins can serve as a key defense mechanism to repress TEs, offering genomic protection. Notably, the family of KRAB-ZNF genes evolves rapidly and exhibits diverse expression pattern...

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Literature Corpus work: 64931126-4769-5843-9b7d-e79e5c6c261b
DOI: 10.1101/2023.12.18.569574

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