Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons.

Nature - 11 Dec 2014

Jacobs Frank M J, Greenberg David, Nguyen Ngan, Haeussler Maximilian, Ewing Adam D, Katzman Sol, Paten Benedict, Salama Sofie R, Haussler David

Abstract excerpt

Throughout evolution primate genomes have been modified by waves of retrotransposon insertions. For each wave, the host eventually finds a way to repress retrotransposon transcription and prevent further insertions. In mouse embryonic stem cells, transcriptional silencing of retrotransposons requires KAP1 (also known as TRIM28) and its repressive complex, which can be recruited to target sites by KRAB zinc-finger...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Embryonic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Kruppel-Like Transcription Factors

Share to Primates

Share to Retroelements

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 25274305
DOI: 10.1038/nature13760
PMCID: PMC4268317

Genes

ZNF93
ZNF91
TRIM28

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An evolutionary arms race between KRAB zinc-finger genes ZNF91/93 and SVA/L1 retrotransposons.PMID 25274305Read ↗

KRAB Zinc Finger Proteins coordinate across evolutionary time scales to battle retroelementsSemantic proximity Read ↗

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neuronsSemantic proximity Read ↗

Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and diseaseSemantic proximity Read ↗

Non-essential function of KRAB zinc finger gene clusters in retrotransposon suppressionSemantic proximity Read ↗

Rapid sequence and expression divergence suggest selection for novel function in primate-specific KRAB-ZNF genes.Semantic proximity Read ↗

The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements.Semantic proximity Read ↗

A human-specific structural variation at the <i>ZNF558</i> locus controls a gene regulatory network during forebrain developmentSemantic proximity Read ↗

Mini-heterochromatin domains constrain the <i>cis</i> -regulatory impact of SVA transposons in human brain development and diseaseSemantic proximity Read ↗

KRAB-ZFP Repressors Enforce Quiescence of Oncogenic Human HerpesvirusesSemantic proximity Read ↗

Ongoing evolution of KRAB zinc finger protein-coding genes in modern humansSemantic proximity Read ↗

Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and diseaseSemantic proximity Read ↗

KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.