Article

Engineered caspases directly rewire mutant Ras to cell death

2026-08-07

Abstract excerpt

As central executioners of cell death, caspases that activate exclusively in diseased cells would provide powerful and specific therapeutic agents. Natural caspase regulation exhibits two universal features that facilitate the engineering of such caspases: proximity-induced subunit assembly and modular separation of substrate recruitment from catalysis. Here, we take advantage of these features to engineer “Raspas...

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Identifiers and source

Literature Corpus work: 7bf78342-f548-5846-a633-0792b44e6800
DOI: 10.64898/2026.08.06.743376

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