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Article

Specific degrader for fusion oncokinase kills tumors and is augmented by bimodal degrader-siRNA

2025-04-25

Abstract excerpt

Oncogenic fusions of two native proteins are challenging to block without disturbing the parental proteins. A mRNA delivered peptide degrader, selectively eliminates the oncogenic fusions DNAJB1::PRKACA and ATP1B1::PRKACA in fibrolamellar carcinoma (FLC), cholangiocarcinoma and intraductal pancreatic neoplasm, without effect on native PRKACA. Specific degradation reflected structural properties of the fusion prote...

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Identifiers and source

Literature Corpus work
072dde83-f57e-5404-99ff-223b879b56dd
DOI
10.1101/2025.04.24.650501
Open publication

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Specific degrader for fusion oncokinase kills tumors and is augmented by bimodal degrader-siRNADOI 10.1101/2025.04.24.650501
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