Article
Targeting RAS-mutant cancer cells using a synthetic RAS-activated cancer killing system.
Trends in biotechnology - 1 Dec 2025
Teng Fei, Gao Qingqin, Zhou Li, Cui Tongtong, Tan Xiangtian, Ding Yali, Li Rongqi, Li Bojin, Zhong Bei, Miao Miao, Zhou Qi, Li Wei
Abstract excerpt
Despite being the most commonly mutated proteins in cancer, oncogenic RAS proteins remain largely untapped as pharmacological targets. Here, we report a synthetic cancer-killing platform, termed 'RAS-activated cancer killing (RACK)' system. Leveraging a transcriptional sensor designed to detect oncogenic RAS signals with high specificity, RACK achieves targeted identification and elimination of RAS-mutant cancer...
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