Article
Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells.
Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2013
Kurokawa Manabu, Ito Takahiro, Yang Chih-Sheng, Zhao Chen, Macintyre Andrew N, Rizzieri David A, Rathmell Jeffrey C, Deininger Michael W, Reya Tannishtha, Kornbluth Sally
Abstract excerpt
Increased understanding of the precise molecular mechanisms involved in cell survival and cell death signaling pathways offers the promise of harnessing these molecules to eliminate cancer cells without damaging normal cells. Tyrosine kinase oncoproteins promote the genesis of leukemias through both increased cell proliferation and inhibition of apoptotic cell death. Although tyrosine kinase inhibitors, such as...
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