Article
Targeted cancer cell killing by highly selective miRNA-triggered activation of a prokaryotic toxin-antitoxin system
2019-07-08
Abstract excerpt
Although not evolved to function in eukaryotes, prokaryotic toxin Kid induces apoptosis in human cells, and this is avoided by co-expression of its neutralizing antitoxin, Kis. Inspired by the way Kid becomes active in bacterial cells we had previously engineered a synthetic toxin-antitoxin system bearing a Kis protein variant that is selectively degraded in cells expressing viral oncoprotein E6, thus achieving hi...
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Identifiers and source
- Literature Corpus work
- 4951e9fa-88b4-5edd-ba61-f83b4691cfae
- DOI
- 10.1101/695114