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Synonymous lysine codon usage modification in a mobile antibiotic resistance gene similarly alters protein production in bacterial species with divergent lysine codon usage biases because it removes a duplicate AAA lysine codon

2018-04-03

Abstract excerpt

The mobile antibiotic resistance gene bla IMP-1 is clinically important and has a synonymous AAA:AAG lysine codon usage bias of 73:27. This bias is like that seen in experimentally determined highly expressed genes in Escherichia coli and Acinetobacter baumanii , but quite different from that seen in Pseudomonas aeruginosa (26:74 AAA:AAG). Here we show that, paradoxically, shifting the AAA:AAG lysine codon bia...

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Literature Corpus work: 7bda87ea-25c6-5e14-a563-aa9ba5f6f58a
DOI: 10.1101/294173

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