Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of specific pbp5 mutations on expression of beta-lactam resistance in Enterococcus faecium.

Antimicrobial agents and chemotherapy - 1 Aug 2004

Rice Louis B, Bellais Samuel, Carias Lenore L, Hutton-Thomas Rebecca, Bonomo Robert A, Caspers Patrick, Page Malcolm G P, Gutmann Laurent

Abstract excerpt

We tested the impact of individual PBP 5 mutations on expression of ampicillin resistance in Enterococcus faecium using a shuttle plasmid designed to facilitate expression of cloned pbp5 in ampicillin-susceptible E. faecium D344SRF. Substitutions that had been implicated in contributing to the resistance of clinical strains conferred only modest levels of resistance when they were present as single point...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ampicillin Resistance
Share to beta-Lactam Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enterococcus faecium

Share to Hexosyltransferases

Share to Muramoylpentapeptide Carboxypeptidase

Share to Penicillin-Binding Proteins

Share to Penicillins

Share to Peptidyl Transferases

Source

Open in PubMed Open full text

Identifiers

PMID: 15273117
DOI: 10.1128/AAC.48.8.3028-3032.2004
PMCID: PMC478487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of specific pbp5 mutations on expression of beta-lactam resistance in Enterococcus faecium.PMID 15273117Read ↗

Role of Penicillin-Binding Protein 5 in Expression of Ampicillin Resistance and Peptidoglycan Structure in Enterococcus faeciumSemantic proximity Read ↗

Analysis of PBP5 of Early U.S. Isolates of Enterococcus faecium: Sequence Variation Alone Does Not Explain Increasing Ampicillin Resistance over TimeSemantic proximity Read ↗

Polymorphisms of the pbp5 gene and correlation with ampicillin resistance in Enterococcus faecium isolates of animal origin.Semantic proximity Read ↗

Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium.Semantic proximity Read ↗

Penicillin-binding protein 5 sequence alterations in clinical isolates of Enterococcus faecium with different levels of beta-lactam resistance.Semantic proximity Read ↗

Differential Penicillin-Binding Protein 5 (PBP5) Levels in the Enterococcus faecium Clades with Different Levels of Ampicillin Resistance.Semantic proximity Read ↗

<i>Enterococcus faecium</i> Low-Affinity <i>pbp5</i> Is a Transferable DeterminantSemantic proximity Read ↗

Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC Enterococcus faecium natural isolate.Semantic proximity Read ↗

Enterococcus faecium PBP5-S/R, the missing link between PBP5-S and PBP5-R.Semantic proximity Read ↗

Polymorphism in pbp5 gene detected in clinical Enterococcus faecium strains with different ampicillin MICs from a Tunisian hospital.Semantic proximity Read ↗

Modification of penicillin-binding protein 5 associated with high-level ampicillin resistance in Enterococcus faeciumSemantic proximity Read ↗

Structure of the low-affinity penicillin-binding protein 5 PBP5fm in wild-type and highly penicillin-resistant strains of Enterococcus faeciumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.