Article
Unraveling the causes of adaptive benefits of synonymous mutations in TEM-1 β-lactamase.
Heredity - 1 Nov 2018
Zwart Mark P, Schenk Martijn F, Hwang Sungmin, Koopmanschap Bertha, de Lange Niek, van de Pol Lion, Nga Tran Thi Thuy, Szendro Ivan G, Krug Joachim, de Visser J Arjan G M
Abstract excerpt
While synonymous mutations were long thought to be without phenotypic consequences, there is growing evidence they can affect gene expression, protein folding, and ultimately the fitness of an organism. In only a few cases have the mechanisms by which synonymous mutations affect the phenotype been elucidated. We previously identified 48 mutations in TEM-1 β-lactamase that increased resistance of Escherichia coli...
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