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Article

Large-Effect Beneficial Synonymous Mutations Mediate Rapid and Parallel Adaptation in a Bacterium.

Molecular biology and evolution - 1 Jun 2016

Agashe Deepa, Sane Mrudula, Phalnikar Kruttika, Diwan Gaurav D, Habibullah Alefiyah, Martinez-Gomez Norma Cecilia, Sahasrabuddhe Vinaya, Polachek William, Wang Jue, Chubiz Lon M, Marx Christopher J

Abstract excerpt

Contrary to previous understanding, recent evidence indicates that synonymous codon changes may sometimes face strong selection. However, it remains difficult to generalize the nature, strength, and mechanism(s) of such selection. Previously, we showed that synonymous variants of a key enzyme-coding gene (fae) of Methylobacterium extorquens AM1 decreased enzyme production and reduced fitness dramatically. We now...

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Identifiers

PMID: 26908584
DOI: 10.1093/molbev/msw035
PMCID: PMC4868122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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