Article

<i>Park7</i> deletion leads to age- and sex-specific transcriptome changes involving NRF2-CYP1B1 axis in mouse midbrain astrocytes

2024-02-23

Abstract excerpt

<h4>Abstractdispe</h4> Loss-of-function mutations in PARK7 , encoding for DJ-1, can lead to early onset Parkinson’s disease (PD). In mice, Park7 deletion leads to dopaminergic deficits during aging, and increased sensitivity to oxidative stress. However, the severity of the reported phenotypes varies. To understand the early molecular changes upon loss of DJ-1, we performed transcriptomic profiling of midbrain...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7bc88ce5-75fe-551f-8035-1446cf40b01d
DOI: 10.1101/2024.02.23.581743

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Park7</i> deletion leads to age- and sex-specific transcriptome changes involving NRF2-CYP1B1 axis in mouse midbrain astrocytesDOI 10.1101/2024.02.23.581743Read

Park7 deletion leads to sex-specific transcriptome changes involving NRF2-CYP1B1 axis in mouse midbrain astrocytesSemantic proximity Read

Nigral Transcriptomic Profiles in Engrailed-1 Hemizygous Mouse Models of Parkinson’s Disease Reveal Upregulation of Oxidative Phosphorylation-Related Genes Associated with Resistance to Dopaminergic NeurodegenerationSemantic proximity Read

Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and genderSemantic proximity Read

Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes.Semantic proximity Read

Skeletal muscle‐specific DJ‐1 ablation‐induced atrogenes expression and mitochondrial dysfunction contributing to muscular atrophySemantic proximity Read

DJ-1 mediates regulation of metabolism and immune response in Parkinson’s disease astrocytes and Glioblastoma cellsSemantic proximity Read

Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During AgingSemantic proximity Read

Evidence for Gender-Specific Transcriptional Profiles of Nigral Dopamine Neurons in Parkinson DiseaseSemantic proximity Read

Compromised retinoic acid receptor beta (RARβ) accelerates the onset of motor, cellular and molecular abnormalities in mouse model of Huntington’s diseaseSemantic proximity Read

Parallel gene expression changes in ventral midbrain dopamine and GABA neurons during normal agingSemantic proximity Read

Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neuronsSemantic proximity Read

<i>Pituitary Tumor Transforming Gene 1</i> orchestrates gene regulatory variation in mouse ventral midbrain during agingSemantic proximity Read