Article

Compromised retinoic acid receptor beta (RARβ) accelerates the onset of motor, cellular and molecular abnormalities in mouse model of Huntington’s disease

2024-03-27

Abstract excerpt

<h4>ABSTRACT</h4> The mechanisms underlying detrimental effects of mutant huntingtin on striatal dysfunction in Huntington’s disease (HD) are not well understood. Although retinoic acid receptor beta (RARβ) emerged recently as one of the top regulators of transcriptionally downregulated genes in the striatum of HD patients and mouse models of HD its involvement in disease progression remains elusive. We report th...

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Literature Corpus work: 89288f60-79a4-584c-9897-28b37ab595ef
DOI: 10.1101/2024.03.23.586058

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Compromised retinoic acid receptor beta (RARβ) accelerates the onset of motor, cellular and molecular abnormalities in mouse model of Huntington’s diseaseDOI 10.1101/2024.03.23.586058Read

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