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Article

Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes.

Toxicology letters - 10 Feb 2009

Ashley Amanda K, Hanneman William H, Katoh Takeshi, Moreno Julie A, Pollack Ashley, Tjalkens Ronald B, Legare Marie E

Abstract excerpt

DJ-1 mutation induces early-onset Parkinson's disease, and conversely over-expression of DJ-1 is associated with cancer in numerous tissues. A gene-trap screening library conducted in embryonic stem cells was utilized for generation of a DJ-1 mutant mouse. Real-time PCR and immunoblotting were utilized to confirm functional mutation of the DJ-1 gene. Normal DJ-1 protein expression in adult mouse tissue was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19063952
DOI: 10.1016/j.toxlet.2008.11.008
PMCID: PMC4632527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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