Article

Multi-omics evaluation of cell lines as models for metastatic prostate cancer

2025-07-22

Abstract excerpt

Cell lines are indispensable tools in prostate cancer research yet their suitability as models for distance metastasis remains incompletely characterized. Here, we conduct a systematic evaluation study using large-scale public multi-omics data. We reveal substantial genomic differences between cell lines and metastatic patient samples, and meanwhile pinpoint cell lines which more closely resemble metastatic prosta...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7bba30cd-74f5-572f-a66b-15f975db69ae
DOI: 10.1101/2025.07.17.665334

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-omics evaluation of cell lines as models for metastatic prostate cancerDOI 10.1101/2025.07.17.665334Read

Multi-omics evaluation of cell lines as models for metastatic prostate cancer.Semantic proximity Read

How clinically relevant and inclusive are prostate cell lines?Semantic proximity Read

How clinically relevant are prostate cancer cell lines? A comprehensive characterisation and multiomics comparisonSemantic proximity Read

Clonal diversity revealed by morphoproteomic and copy number profiles of single prostate cancer cells at diagnosisSemantic proximity Read

A modular patient-derived organoid–xenograft platform reveals molecular and clinical trajectories of prostate cancer progressionSemantic proximity Read

Single-cell omics traces the heterogeneity of prostate cancer cells and the tumor microenvironmentSemantic proximity Read

Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell statesSemantic proximity Read

Single-cell genomic analysis of cancer cells from one treatment-naïve patient with metastatic prostate cancer.Semantic proximity Read

ECM-free patient-derived organoids preserve diverse prostate cancer lineages and uncover <i>in vitro</i> -enriched cell typesSemantic proximity Read

Generation of prostate cancer assembloids modeling the patient-specific tumor microenvironmentSemantic proximity Read

Organoids: An Emerging Precision Medicine Model for Prostate Cancer ResearchSemantic proximity Read

Identification of epithelial and mesenchymal circulating tumor cells in clonal lineage of an aggressive prostate cancer caseSemantic proximity Read