How clinically relevant and inclusive are prostate cell lines?

Abstract excerpt

<title>Abstract</title> <p>Cell line experiments arguably remain the most used tool in preclinical cancer research. Given that PCa cell lines form a major part of this preclinical framework, evaluating their relevance is crucial to improving the predictive power of early-stage research. A range of in silico, in vitro, in vivo and ex vivo approaches are gaining popularity. However, the plethora of historical data...

Topics

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• Cell Line, Tumor
• Gene Expression Regulation, Neoplastic
• Multiomics
• Mutation
• Neoplasm Metastasis
• Prostatic Neoplasms
• Transcriptome
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

5037309c-8fce-5cc9-a712-5e034149ed7d

DOI

10.21203/rs.3.rs-6355469/v1