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How clinically relevant are prostate cancer cell lines? A comprehensive characterisation and multiomics comparison

2024-03-21

Abstract excerpt

Cell line experiments arguably remain the most used tool in preclinical cancer research, despite their limitations. With almost 95% drugs entering human trials failing, and up to 90% preclinical research failing before even being tested in humans, we must shift the pre-clinical paradigm. A range of in silico, in vitro, in vivo and ex vivo approaches are gaining popularity, with the aim of potentially replacing cel...

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Literature Corpus work
cacc50dc-3aeb-5b51-be00-dde15ed40534
DOI
10.1101/2024.03.20.585982
Open publication

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