Article
Sensor Array-Enabled Identification of Drugs for Repolarization of Macrophages to Anti-Inflammatory Phenotypes.
Analytical chemistry - 15 Aug 2023
Jiang Mingdi, Chattopadhyay Aritra Nath, Jeon Taewon, Zhang Xianzhi, Rotello Vincent M
Abstract excerpt
Macrophages are key components of the innate immune system that have essential functions in physiological processes and diseases. The phenotypic plasticity of macrophages allows cells to be polarized into a multidimensional spectrum of phenotypes, broadly classed as pro-inflammatory (M1) and anti-inflammatory (M2) states. Repolarization of M1 to M2 phenotypes alters the immune response to ameliorate autoimmune...
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