Article
Methods and Study Designs for Characterizing the Pharmacokinetics and Pharmacodynamics of Carrier-Mediated Agents.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018
Schorzman Allison N, Lucas Andrew T, Kagel John R, Zamboni William C
Abstract excerpt
Major advances in carrier-mediated agents (CMAs), which include nanoparticles, nanosomes, and conjugates, have revolutionized drug delivery capabilities over the past decade. While providing numerous advantages, such as greater solubility, duration of exposure, and delivery to the site of action over their small molecule counterparts, there is substantial variability in systemic clearance and distribution, tumor...
Topics
- Animals
- Drug Carriers
- Drug Delivery Systems
- Humans
- Nanoparticles
- Pharmacokinetics
- Phenotype