Article

Deleterious mitochondrial heteroplasmy drives high-risk clonal hematopoiesis and hematological malignancy

2026-06-24

Abstract excerpt

Mitochondrial DNA (mtDNA) heteroplasmy, the coexistence of multiple mtDNA variants within cells, accumulates with age and is associated with hematological malignancies and mortality. However, whether predicted deleterious heteroplasmies causally contribute to cancer or merely represent passenger mutations remains unresolved. Here, leveraging ∼36,000 first-degree relative pairs from the UK Biobank and All of Us Res...

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Literature Corpus work: 54ecf2c2-526e-5a99-b705-e9943ab979bc
DOI: 10.64898/2026.06.22.26356227

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